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Description for Protein PDE4A

phosphodiesterase 4A, cAMP-specific
6 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. PDE4A is a class IV cAMP-specific PDE (summary by Milatovich et al., 1994 [PubMed 8009369]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • HDc: Metal dependent phosphohydrolases with conserved 'HD' motif.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.4.17
    KEGG - Orthology:
    K01120
    KEGG - Pathway(s):
    hsa00230
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PDE46; DPDE2
    Approved Symbol:
    PDE4A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 21
    Human (de-) phosphorylation sites: 21; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one(db);
  • 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid(db);
  • Dipyridamole(db);
  • Drotaverine(db);
  • Dyphylline(db);
  • Enprofylline(db);
  • Ibudilast(db);
  • Iloprost(db);
  • Ketotifen(db);
  • Oxtriphylline(db);
  • Pentoxifylline(db);
  • Piclamilast(db);
  • Theophylline(db);
  • Tofisopam(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02527 Entrez Gene ID: 5141 OMIM ID: 600126 Swissprot Accession: P27815;