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Description for Protein PDE3A

phosphodiesterase 3A, cGMP-inhibited
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/2)
(cAMP/cGMP binding: 1; phosphoproteome: 1; platelet: 1; undefined: 2)
Summary:
Cyclic nucleotide phosphodiesterases (PDEs) comprise a complex group of enzymes, and at least 5 major PDE families or classes with distinctive properties have been identified. Members of the cGMP-inhibited cAMP PDE (cGI-PDE) family, such as PDE3A, are characterized by high affinity for cAMP and cGMP and competitive inhibition of their cAMP hydrolytic activity by cGMP and certain positive inotropic agents (Meacci et al., 1992 [PubMed 1315035]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.4.17
    KEGG - Orthology:
    K13296
    KEGG - Pathway(s):
    hsa00230; hsa04910; hsa04914
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    cAMP phosphodiesterase myocardinal cGMP inhibited; cGMP inhibited 3`,5`-cyclic phosphodiesterase A; Cyclic GMP inhibited phosphodiesterase A; CGI PDE A; EC 3.1.4.17
    Approved Symbol:
    PDE3A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 22
    Human (de-) phosphorylation sites: 22; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Aminophylline(db);
  • Amrinone(db);
  • Anagrelide(db);
  • Cilostazol(db);
  • Enoximone(db);
  • Ibudilast(db);
  • Levosimendan(db);
  • Milrinone(db);
  • Oxtriphylline(db);
  • Theophylline(db);
  • Tofisopam(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 5
    • Additional Identifiers:

    HPRD: 00441 Entrez Gene ID: 5139 OMIM ID: 123805 Swissprot Accession: Q14432;