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Description for Protein ATP6V1D

ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.3.14
    KEGG - Orthology:
    K02149
    KEGG - Pathway(s):
    hsa00190; hsa01100; hsa04966; hsa05110; hsa05120
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    VATD; VMA8; ATP6M; VATPase D subunit; Vacuolar HATPase subunit D; Vacuolar proton pump D subunit; Vacuolar ATP synthase subunit D; Vacuolar proton ATPase subunit D; VATPase 28 kDa accessory protein; Vacuolar proton pump delta polypeptide; ATPase, H+ transporting lysosomal, member M; H(+)-transporting two-sector ATPase, subunit M; ATPase, H+ transporting, lysosomal vacuolar proton pump; ATPase, H+ transporting, lysosomal, 28 kD accessory protein; EC 3.6.3.14
    Approved Symbol:
    ATP6V1D
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 16524 Entrez Gene ID: 51382 OMIM ID: 609398 Swissprot Accession: Q9Y5K8;