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Description for Protein PDE1A

phosphodiesterase 1A, calmodulin-dependent
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • HDc: Metal dependent phosphohydrolases with conserved 'HD' motif.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.4.17
    KEGG - Orthology:
    K13755
    KEGG - Pathway(s):
    hsa00230; hsa04020; hsa04742
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    HCAM1; Calcium/calmodulin-dependent 3`,5`-cyclic nucleotide phosphodiesterase 1A; Cam-PDE 1A; 61 kDa Cam-PDE; PDE1A1; EC 3.1.4.17; Phosphodiesterase 1A, calmodulin dependent isoform 1; Phosphodiesterase 1A, calmodulin dependent isoform 2
    Approved Symbol:
    PDE1A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Bepridil(db);
  • Felodipine(db);
  • Nicardipine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01387 Entrez Gene ID: 5136 OMIM ID: 171890 Swissprot Accession: P54750;