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Description for Protein CDK16

cyclin-dependent kinase 16
14 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 4)
Summary:
The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.22
    KEGG - Orthology:
    K08820
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Serine/threonine-protein kinase PCTAIRE-1; PCTAIRE1; FLJ16665; PCTAIRE; PCTGAIRE; EC 2.7.1.37; PCTAIRE-motif protein kinase 1
    Approved Symbol:
    CDK16
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 50
    Human (de-) phosphorylation sites: 50; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 1
    Human phosphorylation targets: 1; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02409 Entrez Gene ID: 5127 OMIM ID: 311550 Swissprot Accession: Q00536;