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Description for Protein DUSP13

dual specificity phosphatase 13
4 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • DSPC: Dual specificity phosphatase, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.16; 3.1.3.48
    KEGG - Orthology:
    K01090
    K01104
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    OTTHUMP00000060197; Dual-specificity phosphatase SKRP4; Testis and skeletal muscle-specific dual specificity phosphatase isoform 3; Branching enzyme interacting dual specificity protein phosphatase; BEDP; FLJ32450; Testis and skeletal muscle specific DSP; Muscle restricted dual specificity phosphatase; Testis and skeletal muscle specific dual specificity phosphatase; EC 3.1.3.48; EC 3.1.3.16; SKRP4; Testis and skeletal muscle-specific dual specificity phosphatase isoform 2; Testis and skeletal muscle-specific dual specificity phosphatase isoform 6; TMDP; Muscle-restricted dual specificity phosphatase isoform 1; MDSP; Muscle-restricted dual specificity phosphatase isoform 4; Muscle-restricted dual specificity phosphatase isoform 5; TMDP-L1; TMDP-L2
    Approved Symbol:
    DUSP13
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 13251 Entrez Gene ID: 51207 OMIM ID: 613191 Swissprot Accession: Q9UII6; Q6B8I1;