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Description for Protein GP6

glycoprotein VI (platelet)
7 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/2)
(membrane: 2; platelet: 4; secretome: 3; undefined: 1)
Summary:
Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke (Jandrot-Perrus et al., 2000 [PubMed 10961879]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • IG: Immunoglobulin
  • IGC2: Immunoglobulin C-2 Type
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06264
    KEGG - Pathway(s):
    hsa04512
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    GPVI; Glycoprotein VI platelet; Glycoprotein VI (platelet) isoform 1
    Approved Symbol:
    GP6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 1
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 10406 Entrez Gene ID: 51206 OMIM ID: 605546 Swissprot Accession: Q9HCN6;