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Description for Protein DCXR

dicarbonyl/L-xylulose reductase
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 5/1)
(membrane: 1; platelet: 3; secretome: 3; undefined: 1)
Summary:
The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene. (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.1.1.10
KEGG - Orthology:
K03331
KEGG - Pathway(s):
hsa00040; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
DCR; P34H; HCRII; KIDCR; Carbonyl reductase; Carbonyl reductase II; Kidney dicarbonyl reductase; Dicarbonyl reductase; Diacetyl reductase; L-xylulose reductase; EC 1.1.1.10; XR; KiDCR; Sperm surface protein P34H
Approved Symbol:
DCXR
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2'-Monophosphoadenosine 5'-Diphosphoribose(db);
  • Dihydrogenphosphate Ion(db);
  • Isopropyl Alcohol(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 16320 Entrez Gene ID: 51181 OMIM ID: 608347 Swissprot Accession: Q7Z4W1;