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Description for Protein COPS4

COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
21 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 7)
Summary:
This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PINT: motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12178
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    MGC10899; MGC15160; COP9 constitutive photomorphogenic homolog subunit 4
    Approved Symbol:
    COPS4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09888 Entrez Gene ID: 51138 OMIM ID: - Swissprot Accession: Q9BT78; B3KM48;