Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein IRAK4

interleukin-1 receptor-associated kinase 4
10 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 5)
Summary:
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [supplied by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • DEATH: DEATH domain, found in proteins involved in cell death (apoptosis).
  • S_T_Y_Kinase: Protein kinase
  • unclassified specificity
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K04733
    KEGG - Pathway(s):
    hsa04210; hsa04620; hsa04722; hsa05140; hsa05142
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    REN64; Interleukin 1 receptor associated kinase 4
    Approved Symbol:
    IRAK4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 21
    Human (de-) phosphorylation sites: 21; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 3
    Human phosphorylation targets: 3; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1-(3-HYDROXYPROPYL)-2-[(3-NITROBENZOYL)AMINO]-1H-BENZIMIDAZOL-5-YL PIVALATE(db)

    Associated Genetic Diseases:

  • Invasive pneumococcal disease, recurrent isolated, 1(Pd);
  • IRAK4 deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06051 Entrez Gene ID: 51135 OMIM ID: 606883 Swissprot Accession: Q9NWZ3; B4E359; B2RAP9;