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Description for Protein TRNT1

tRNA nucleotidyl transferase, CCA-adding, 1
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 4)
Summary:
The CCA-adding enzyme TRNT1 (EC 2.7.7.25) is an essential enzyme that catalyzes the addition of the CCA terminus to the 3-prime end of tRNA precursors. This reaction is a fundamental prerequisite for mature tRNAs to become aminoacylated and to participate in protein biosynthesis (Lizano et al., 2007 [PubMed 17204286]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.7.21; 2.7.7.25; 3.1.3.-; 3.1.4.-
    KEGG - Orthology:
    K00974
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    CCA1; MtCCA; CGI47; Mitochondrial CCA adding tRNA nucleotidyltransferase; EC 2.7.7.25; Mt tRNA adenylyltransferase; Mt tRNA CCA pyrophosphorylase; Mt tRNA CCA diphosphorylase; Mt CCAadding enzyme; tRNA nucleotidyltransferase 1, mitochondrial; tRNA nucleotidyl transferase, CCA-adding, 1 isoform 2; tRNA nucleotidyl transferase, CCA-adding, 1 isoform 1
    Approved Symbol:
    TRNT1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 18227 Entrez Gene ID: 51095 OMIM ID: 612907 Swissprot Accession: Q96Q11;