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Description for Protein SEPSECS

Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The 21st amino acid, selenocysteine (sec), is distinct from other amino acids because it lacks its own tRNA synthetase and is the only amino acid synthesized on its cognate tRNA. Synthesis of sec begins with acylation of tRNA(sec) (TRSP; MIM 165060) by seryl-tRNA synthetase (SARS; MIM 607529) to give ser-tRNA(sec), which is subsequently phosphorylated by O-phosphoseryl-tRNA kinase (PSTK; MIM 611310) to give O-phosphoseryl-tRNA(sec). SEPSECS catalyzes the final step of sec synthesis by converting O-phosphoseryl-tRNA(sec) to selenocysteinyl-tRNA(sec) using selenophosphate as the selenium donor (Palioura et al., 2009 [PubMed 19608919]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.9.1.2
KEGG - Orthology:
K03341
KEGG - Pathway(s):
hsa00970
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
UGA suppressor tRNA-associated protein; SLA/LP autoantigen; Soluble liver antigen; SLA; Liver-pancreas antigen; LP; SLA p35; Soluble liver antigen/liver pancreas antigen isoform 1; Soluble liver antigen/liver pancreas antigen isoform 2; SLA/LP
Approved Symbol:
SEPSECS
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 15
Human (de-) phosphorylation sites: 15; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Pyridoxal Phosphate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11561 Entrez Gene ID: 51091 OMIM ID: 613009 Swissprot Accession: Q9HD40;