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Description for Protein MLXIPL

MLX interacting protein-like
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
  • HLH: helix loop helix domain
  • LZ: Leucine Zipper
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09113
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    MIO; CHREBP; MONDOB; Mondo family member B; Carbohydrate response element binding protein; WS basic helix loop helix leucine zipper protein; Mlx interactor; WBSCR14; WS-bHLH; MLX-interacting protein-like; Williams Beuren syndrome chromosome region 14 isoform alpha; Williams Beuren syndrome chromosome region 14 isoform beta; Williams Beuren syndrome chromosome region 14 isoform gamma; Williams Beuren syndrome chromosome region 14 isoform delta
    Approved Symbol:
    MLXIPL
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 12033 Entrez Gene ID: 51085 OMIM ID: 605678 Swissprot Accession: Q9NP71;