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Description for Protein TXNDC12

thioredoxin domain containing 12 (endoplasmic reticulum)
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
TXNDC12 belongs to the thioredoxin superfamily (see TXN; MIM 187700). Members of this superfamily possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defense against oxidative stress, refolding of disulfide-containing proteins, and regulation of transcription factors (Liu et al., 2003 [PubMed 14557066]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.8.4.2
    KEGG - Orthology:
    K05360
    KEGG - Pathway(s):
    hsa00480
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Endoplasmic reticulum thioredoxin superfamily member 18 kDa; Endoplasmic reticulum protein ERp19; ERP18; ERP19
    Approved Symbol:
    TXNDC12
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Glutathione(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 11633 Entrez Gene ID: 51060 OMIM ID: 609448 Swissprot Accession: O95831; O95881;