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Description for Protein PCK2

phosphoenolpyruvate carboxykinase 2 (mitochondrial)
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 2)
Summary:
This gene encodes a member of the phosphoenolpyruvate carboxykinase (GTP) family. The protein is a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of GTP. A cytosolic form encoded by a different gene has also been characterized and is the key enzyme of gluconeogenesis in the liver. The encoded protein may serve a similar function, although it is constitutively expressed and not modulated by hormones such as glucagon and insulin that regulate the cytosolic form. Alternatively spliced transcript variants have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
4.1.1.32
KEGG - Orthology:
K01596
KEGG - Pathway(s):
hsa00010; hsa00020; hsa00620; hsa01100; hsa03320; hsa04910; hsa04920; hsa04964
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
PEPCK2; Phosphoenolpyruvate carboxylase; PEPCK; PEPCK-M; Mitochondrial phosphoenolpyruvate carboxykinase 2; PEP carboxykinase; Phosphopyruvate carboxylase; Mitochondrial phosphoenolpyruvate carboxykinase 2 isoform 1; Mitochondrial phosphoenolpyruvate carboxykinase 2 isoform 2
Approved Symbol:
PCK2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 5
Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02026 Entrez Gene ID: 5106 OMIM ID: 261650 Swissprot Accession: Q16822;