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Description for Protein PCK1

phosphoenolpyruvate carboxykinase 1 (soluble)
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
4.1.1.32
KEGG - Orthology:
K01596
KEGG - Pathway(s):
hsa00010; hsa00020; hsa00620; hsa01100; hsa03320; hsa04910; hsa04920; hsa04964
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Phosphoenolpyruvate carboxykinase; PEPCK1; PEPCKC; PEP carboxykinase; PEPCK cytosolic
Approved Symbol:
PCK1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1-(2-Fluorobenzyl)-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine(db);
  • 1-Allyl-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine(db);
  • Acetate Ion(db);
  • Phosphoenolpyruvate(db);
  • Phosphomethylphosphonic Acid-Guanylate Ester(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02028 Entrez Gene ID: 5105 OMIM ID: 261680 Swissprot Accession: P35558;