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Description for Protein EXOSC1

exosome component 1
8 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S1: Ribosomal protein S1-like RNA-binding domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07573
    KEGG - Pathway(s):
    hsa03018
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Exosome component 1; CSL4; p13; SKI4; Csl4p; Ski4p; CGI108; 3`-5` exoribonuclease CSL4 homolog
    Approved Symbol:
    EXOSC1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 16223 Entrez Gene ID: 51013 OMIM ID: 606493 Swissprot Accession: Q9Y3B2;