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Description for Protein ACOX1

acyl-CoA oxidase 1, palmitoyl
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/0)
(alpha granules: 1; membrane: 1; microparticles: 1; platelet: 3; secretome: 2)
Summary:
The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.3.3.6
KEGG - Orthology:
K00232
KEGG - Pathway(s):
hsa00071; hsa00592; hsa01040; hsa01100; hsa03320; hsa04146
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
ACOX1 Acyl-CoA oxidase palmitoyl peroxidase Acyl-CoA oxidase; ACOX palmitoyl-CoA oxidase Acyl-CoA oxidase straight-chain; Acyl-Coenzyme A oxidase 1 peroxisomal; Palmitoyl-CoA oxidase; Pseudoneonatal Acyl-CoA oxidase 1 palmitoyl; Acyl-CoA oxidase, palmitoyl, peroxisomal; Acyl CoA oxidase straight chain; ACOX; AOX; EC 1.3.3.6; Acyl-Coenzyme A oxidase isoform b
Approved Symbol:
ACOX1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 5
Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • (3R)-3-HYDROXYDODECANOIC ACID(db);
  • Flavin-Adenine Dinucleotide(db)

    Associated Genetic Diseases:

  • Peroxisomal acyl-CoA oxidase deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02030 Entrez Gene ID: 51 OMIM ID: 609751 Swissprot Accession: Q15067;