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Description for Protein ATP5C1

ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
21 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/0)
(membrane: 2; microparticles: 1; platelet: 4)
Summary:
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.6.3.14
KEGG - Orthology:
K02136
KEGG - Pathway(s):
hsa00190; hsa01100; hsa05010; hsa05012; hsa05016
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
ATP synthase H+transporting mitochondrial F1 complex gamma subunit 1; ATP5C; Mitochondrial ATP synthase gamma subunit 1; ATP synthase gamma chain mitochondrial; EC 3.6.3.14; ATP synthase H+ transporting mitochondrial F1 complex gamma subunit isoform H (heart) precursor; ATP synthase, H+ transporting, mitochondrial F1 complex, gamma subunit isoform L (liver) precursor
Approved Symbol:
ATP5C1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 4
Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1-ACETYL-2-CARBOXYPIPERIDINE(db);
  • AUROVERTIN B(db);
  • N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE(db);
  • PICEATANNOL(db);
  • Quercetin(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00156 Entrez Gene ID: 509 OMIM ID: 108729 Swissprot Accession: Q6I9V2; P36542; Q8TAS0;