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Description for Protein F11R

F11 receptor
15 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 11/2)
(alpha granules: 1; membrane: 2; microparticles: 1; phosphoproteome: 1; platelet: 5; secretome: 2; undefined: 2)
Summary:
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • Ig_LIKE: Immunoglobulin like
  • TM: Transmembrane domain
  • IGV: Immunoglobulin V-Type
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06089
    KEGG - Pathway(s):
    hsa04514; hsa04530; hsa04670; hsa05120
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    JAM; JAM1; JCAM; KAT; PAM-1; F11 receptor 1; Platelet adhesion molecule; Junctional adhesion molecule A; JAMA; CD321 antigen; Platelet adhesion molecule 1
    Approved Symbol:
    F11R
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 32
    Human (de-) phosphorylation sites: 32; Platelet phosphorylation sites: 2
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 2
  • Isoform 4 : 1
  • Isoform 3 : 2
  • Isoform 2 : 2
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 12038 Entrez Gene ID: 50848 OMIM ID: 605721 Swissprot Accession: Q9Y624; Q6FIB4;