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Description for Protein PARK2

parkinson protein 2, E3 ubiquitin protein ligase (parkin)
66 total interacting proteins; 30 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • UBQ: Ubiquitin homologues
  • IBR: In Between Ring fingers
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.3.2.19
    KEGG - Orthology:
    K04556
    KEGG - Pathway(s):
    hsa04120; hsa05012
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PRKN; PDJ; AR-JP; Parkin; E3 ubiquitin ligase; EC 6.3.2; Ubiquitin E3 ligase PRKN; Parkinson juvenile disease protein 2; Parkinson disease protein 2; Parkin isoform 1; Parkin isoform 2; Parkin isoform 3
    Approved Symbol:
    PARK2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 10
    Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Adenocarcinoma of lung, somatic(Pd);
  • Adenocarcinoma, ovarian, somatic(Pd);
  • Parkinson disease 2, autosomal recessive juvenile(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03967 Entrez Gene ID: 5071 OMIM ID: 602544 Swissprot Accession: O60260; Q5VVX3; Q5VVX4;