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Description for Protein PAPPA

pregnancy-associated plasma protein A, pappalysin 1
11 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • LAMGL: LamG-like jellyroll fold domain
  • SUSHI: Sushi domain (SCR repeat)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.24.79
    KEGG - Orthology:
    K07762
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    PAPA; Igf dependent Igfbp4 protease; Insulin like growth factor dependent Igf binding protein 4 protease; IGFBP4ase
    Approved Symbol:
    PAPPA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01448 Entrez Gene ID: 5069 OMIM ID: 176385 Swissprot Accession: Q13219; Q86YM8; Q8IWT8;