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Description for Protein PAM

peptidylglycine alpha-amidating monooxygenase
8 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL). These catalytic domains work sequentially to catalyze neuroendocrine peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene but some of their full length sequences are not yet known. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.14.17.3
    KEGG - Orthology:
    K00504
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Peptidylglycine alpha hydroxylating monooxygenase; Peptidylglycine 2-hydroxylase; Peptidyl alpha amidating enzyme; Peptidyl alpha hydroxyglycine alpha amidating lyase; Pancreatic peptidylglycine alpha amidating monooxygenase
    Approved Symbol:
    PAM
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 30
    Human (de-) phosphorylation sites: 30; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • N-Alpha-Acetyl-3,5-Diiodotyrosylglycine(db);
  • Threonine Derivative(db);
  • Vitamin C(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 1
  • Isoform 2 : 0
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01361 Entrez Gene ID: 5066 OMIM ID: 170270 Swissprot Accession: A6NMR0; P19021;