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Description for Protein PAK2

p21 protein (Cdc42/Rac)-activated kinase 2
51 total interacting proteins; 30 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 5/1)
(phosphoproteome: 1; platelet: 4; undefined: 1)
Summary:
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • PBD: P21-Rho-binding domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K04410
    KEGG - Pathway(s):
    hsa04010; hsa04012; hsa04360; hsa04510; hsa04660; hsa04810; hsa05211
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    p21 activated kinase 2; PAK65; p21 activated kinase 65KD; p21 (CDKN1A) activated kinase 2i; Serine/threonine kinase PAK 2; Gamma PAK; S6/H4 kinase
    Approved Symbol:
    PAK2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 20
    Human (de-) phosphorylation sites: 20; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 10
    Human phosphorylation targets: 10; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05428 Entrez Gene ID: 5062 OMIM ID: 605022 Swissprot Accession: Q13177; A8K5M4;