Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein PAK1

p21 protein (Cdc42/Rac)-activated kinase 1
88 total interacting proteins; 45 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 2; undefined: 1)
Summary:
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • PBD: P21-Rho-binding domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K04409
    KEGG - Pathway(s):
    hsa04010; hsa04012; hsa04062; hsa04360; hsa04510; hsa04650; hsa04660; hsa04666; hsa04810; hsa05120; hsa05211
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    p21 activated kinase 1; P65 PAK; PAK; PAKalpha; MGC130000; MGC130001; Serine/threonine-protein kinase PAK 1; EC 2.7.11.1; PAK-1; Alpha-PAK
    Approved Symbol:
    PAK1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 28
    Human (de-) phosphorylation sites: 28; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 45
    Human phosphorylation targets: 40; Predicted platelet targets: 5
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03995 Entrez Gene ID: 5058 OMIM ID: 602590 Swissprot Accession: Q13153;