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Description for Protein SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
17 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 8/1)
(alpha granules: 1; microparticles: 1; platelet: 4; secretome: 2; undefined: 1)
Summary:
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • SERPIN: SERine Proteinase INhibitors
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03982
    KEGG - Pathway(s):
    hsa04115; hsa04610; hsa05142
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PAI1; PAI; PLANH1; Serpine 1; Plasminogen activator inhibitor, beta migrating endothelial cell derived type; PAIE; Endothelial plasminogen activator inhibitor
    Approved Symbol:
    SERPINE1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alteplase(db);
  • Anistreplase(db);
  • Dimethyl sulfoxide(db);
  • Drotrecogin alfa(db);
  • Reteplase(db);
  • Tenecteplase(db);
  • Troglitazone(db);
  • Urokinase(db)

    Associated Genetic Diseases:

  • Plasminogen activator inhibitor 1 deficiency(Pd);
  • Plasminogen activator inhibitor polymorphism(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01418 Entrez Gene ID: 5054 OMIM ID: 173360 Swissprot Accession: P05121; B7Z4S0;