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Description for Protein PRDX1

peroxiredoxin 1
13 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 11/1)
(alpha granules: 1; membrane: 2; microparticles: 1; platelet: 7; secretome: 2)
Summary:
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.11.1.15
KEGG - Orthology:
K13279
KEGG - Pathway(s):
hsa04146
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
EC 1.11.1.15; Proliferation associated gene A; PAGA Natural killer enhancing factor A; NKEFA; Thioredoxin peroxidase 2; Thioredoxin dependent peroxide reductase 2; Proliferation associated protein PAG; Natural killer cell enhancing factor A; NKEF-A; TDPX2; PAGB; PAGA; PAG; MSP23
Approved Symbol:
PRDX1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 4
Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01458 Entrez Gene ID: 5052 OMIM ID: 176763 Swissprot Accession: Q06830;