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Description for Protein MINK1

misshapen-like kinase 1
13 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(phosphoproteome: 1; platelet: 3; undefined: 1)
Summary:
This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CNH: Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K04413
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Misshapen/NIK related kinase; EC 2.7.1.37; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK6; MAP4K6; MGC21111; GCK family kinase MINK; Serine/threonine protein kinase; B55; ZC3; hMINK; hMINKbeta; Mitogen-activated protein kinase kinase kinase kinase 6; Misshapen/NIK-related kinase isoform 3; Misshapen/NIK-related kinase isoform 4; Misshapen/NIK-related kinase isoform 2; Misshapen/NIK-related kinase isoform 1
    Approved Symbol:
    MINK1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 67
    Human (de-) phosphorylation sites: 67; Platelet phosphorylation sites: 3
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11366 Entrez Gene ID: 50488 OMIM ID: 609426 Swissprot Accession: Q5U8Z0; Q8N4C8;