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Description for Protein RRM2B

ribonucleotide reductase M2 B (TP53 inducible)
7 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described. (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.17.4.1
    KEGG - Orthology:
    K10808
    KEGG - Pathway(s):
    hsa00230; hsa00240; hsa00480; hsa01100; hsa04115
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    P53R2; Ribonucleotide reductase M2 B (TP53 inducible); Ribonucleotide reductase small subunit 2 like, p53 inducible; p53 inducible and ribonucleotide reductase small subunit 2 like
    Approved Symbol:
    RRM2B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Cladribine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 05276 Entrez Gene ID: 50484 OMIM ID: 604712 Swissprot Accession: Q7LG56;