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Description for Protein PCSK6

proprotein convertase subtilisin/kexin type 6
4 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/1)
(alpha granules: 1; membrane: 1; platelet: 8; secretome: 7)
Summary:
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • FU: Furin-like repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.21.-
    KEGG - Orthology:
    K08672
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Subtilisin/kexin like protease PACE4; Subtilisin like proprotein convertase 4; SPC4; Paired basic amino acid cleaving enzyme 4; Paired basic amino acid cleaving system 4 isoform g preproprotein; Paired basic amino acid cleaving system 4 isoform a preproprotein; Paired basic amino acid cleaving system 4 isoform b preproprotein; Paired basic amino acid cleaving system 4 isoform h preproprotein; Paired basic amino acid cleaving system 4 isoform c preproprotein; Paired basic amino acid cleaving system 4 isoform e preproprotein; Paired basic amino acid cleaving system 4 isoform d preproprotein; Paired basic amino acid cleaving system 4 isoform f preproprotein; PACE4; Paired basic amino acid cleaving system 4; Subtilisin-like protease; EC 3.4.21.-
    Approved Symbol:
    PCSK6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 8 : 0
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01329 Entrez Gene ID: 5046 OMIM ID: 167405 Swissprot Accession: P29122;