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Description for Protein P4HB

prolyl 4-hydroxylase, beta polypeptide
23 total interacting proteins; 12 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 10/1)
(alpha granules: 1; membrane: 2; microparticles: 1; platelet: 5; secretome: 1; undefined: 1)
Summary:
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    5.3.4.1
    KEGG - Orthology:
    K09580
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Procollagen proline, 2-oxoglutarate 4-dioxygenase beta subunit; PHDB; Prolyl 4-hydroxylase, beta subunit; PROHB; DSI; Protein disulfide isomerase/oxidoreductase; PDI; Cellular thyroid hormone binding protein p55; Glutathione insulin transhydrogenase; GIT
    Approved Symbol:
    P4HB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Ribostamycin(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07181 Entrez Gene ID: 5034 OMIM ID: 176790 Swissprot Accession: P07237;