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Description for Protein ACO2

aconitase 2, mitochondrial
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 5/0)
(microparticles: 1; platelet: 5; secretome: 2)
Summary:
The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
4.2.1.3
KEGG - Orthology:
K01681
KEGG - Pathway(s):
hsa00020; hsa00630; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Citrate hydrolyase aconitase; Aconitase 2; EC 4.2.1.3
Approved Symbol:
ACO2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 4-Hydroxy-Aconitate Ion(db);
  • Aconitate Ion(db);
  • Alpha-Methylisocitric Acid(db);
  • Isocitric Acid(db);
  • Tricarballylic Acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00012 Entrez Gene ID: 50 OMIM ID: 100850 Swissprot Accession: Q99798;