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Description for Protein OPRM1

opioid receptor, mu 1
15 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The OPRM1 gene encodes the mu opioid receptor, which is the primary site of action for the most commonly used opioids, including morphine, heroin, fentanyl, and methadone. It is also the primary receptor for endogenous opioid peptides beta-endorphin (see POMC, MIM 176830) and the enkephalins (see PENK, MIM 131330). The OPRM1 receptor is a membrane of the G protein-coupled receptor family (Bond et al., 1998 [PubMed 9689128]). There are at least 3 types of opioid receptors, mu, kappa (OPRK1; MIM 165196), and delta (OPRD1; MIM 165195), each with a distinct pharmacologic profile (Chen et al., 1993 [PubMed 8393525]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • TIR: Toll - interleukin 1 - resistance
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04215
    KEGG - Pathway(s):
    hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    OPRM; Mu-type opioid receptor; MOR-1; MOR1; Opioid receptor mu 1 isoform MOR-1X; Opioid receptor mu 1 isoform MOR-1A; Opioid receptor mu 1 isoform MOR-1O; KIAA0403; Mu opiate receptor; Mu opioid receptor
    Approved Symbol:
    OPRM1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 28
    Human (de-) phosphorylation sites: 28; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 3-Methylfentanyl(db);
  • 3-Methylthiofentanyl(db);
  • Alfentanil(db);
  • Alvimopan(db);
  • Anileridine(db);
  • Buprenorphine(db);
  • Butorphanol(db);
  • Carfentanil(db);
  • Codeine(db);
  • Dezocine(db);
  • Dihydromorphine(db);
  • Dimethylthiambutene(db);
  • Diphenoxylate(db);
  • Diprenorphine(db);
  • Ethylmorphine(db);
  • Etorphine(db);
  • Fentanyl(db);
  • Heroin(db);
  • Hydrocodone(db);
  • Hydromorphone(db);
  • Levallorphan(db);
  • Levomethadyl Acetate(db);
  • Levorphanol(db);
  • Loperamide(db);
  • Methadone(db);
  • Methadyl Acetate(db);
  • Morphine(db);
  • Nalbuphine(db);
  • Naloxone(db);
  • Naltrexone(db);
  • Ondansetron(db);
  • Oxycodone(db);
  • Oxymorphone(db);
  • Pentazocine(db);
  • Propoxyphene(db);
  • Remifentanil(db);
  • Sufentanil(db);
  • Tramadol(db)

    Associated Genetic Diseases:

  • Morphine-6-glucuronide, response to(Pd)
    		• Predicted Transmembrane Domains:
    02484_13(6)
    02484_12(7)
    02484_11(7)
    02484_10(7)
  • Isoform 9 : 7
  • Isoform 8 : 7
  • Isoform 7 : 6
  • Isoform 6 : 6
  • Isoform 5 : 7
  • Isoform 4 : 7
  • Isoform 3 : 7
  • Isoform 2 : 7
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 02484 Entrez Gene ID: 4988 OMIM ID: 600018 Swissprot Accession: P35372; B8Q1L8; Q6UPP1;