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Description for Protein OGG1

8-oxoguanine DNA glycosylase
5 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.2.2.-; 4.2.99.18
    KEGG - Orthology:
    K03660
    KEGG - Pathway(s):
    hsa03410
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    8 Hydroxyguanine DNA glycosylase; HOGG1; MUTM; HMMH; OGH1; OGG1 type 1e; N-glycosylase/DNA lyase; DNA-(apurinic or apyrimidinic site) lyase; EC 4.2.99.18; 8-oxoguanine DNA glycosylase isoform 2a; 8-oxoguanine DNA glycosylase isoform 1a; 8-oxoguanine DNA glycosylase isoform 1b; 8-oxoguanine DNA glycosylase isoform 1c; 8-oxoguanine DNA glycosylase isoform 2b; 8-oxoguanine DNA glycosylase isoform 2c; 8-oxoguanine DNA glycosylase isoform 2d; 8-oxoguanine DNA glycosylase isoform 2e; OGG1 type 1d; OGG1 type 1g; OGG1 type 1h
    Approved Symbol:
    OGG1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Renal cell carcinoma, clear cell, somatic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 8 : 0
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03582 Entrez Gene ID: 4968 OMIM ID: 601982 Swissprot Accession: O15527;