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Description for Protein OGDH

oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
4 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 8)
Summary:
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.2.4.2
KEGG - Orthology:
K00164
KEGG - Pathway(s):
hsa00020; hsa00310; hsa00380; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide); Alpha-KGD deficiency; 2-ketoglutarate dehydrogenase deficiency; Oxoglutaricaciduria; Oxoglutarate dehydrogenase; Oxoglutarate dehydrogenase (lipoamide); E1K; Alpha-ketoglutarate dehydrogenase deficiency
Approved Symbol:
OGDH
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • NADH(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08938 Entrez Gene ID: 4967 OMIM ID: 613022 Swissprot Accession: Q02218; B4E3E9; Q96DD3;