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Description for Protein ODC1

ornithine decarboxylase 1
5 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
4.1.1.17
KEGG - Orthology:
K01581
KEGG - Pathway(s):
hsa00330; hsa00480; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
ODCP; ODC2; Ornithine decarboxylase 2; Ornithine decarboxylase
Approved Symbol:
ODC1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alpha-Difluoromethylornithine(db);
  • G418(db);
  • N'-Pyridoxyl-Lysine-5'-Monophosphate(db);
  • N-Pyridoxyl-Glycine-5-Monophosphate(db);
  • Putrescine(db);
  • Pyridoxal Phosphate(db);
  • Pyridoxine-5'-Phosphate(db);
  • Spermine(db)

    Associated Genetic Diseases:

  • Colonic adenoma recurrence, reduced risk of(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01324 Entrez Gene ID: 4953 OMIM ID: 165640 Swissprot Accession: P11926; Q53TU3;