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Description for Protein NR4A2

nuclear receptor subfamily 4, group A, member 2
15 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ZnF_C4: c4 zinc finger in nuclear hormone receptors
  • HOLI: Ligand binding domain of hormone receptors
  • LZ: Leucine Zipper
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08558
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Nuclear receptor related 1; NURR1; Nuclear receptor of T cells; NOT; Transcriptionally inducible nuclear receptor; TINUR; NGFI Bbeta; Orphan nuclear receptor NURR1; Orphan nuclear receptor NR4A2; Immediate early response protein NOT; RNR1; Nuclear receptor subfamily 4, group A, member 2 isoform b; Nuclear receptor subfamily 4, group A, member 2 isoform c; Nuclear receptor subfamily 4, group A, member 2 isoform d; HZF-3; T-cell nuclear receptor NOT; Intermediate-early receptor protein; NGFI-B/nur77 beta-type transcription factor homolog; Transcriptionally inducible nuclear receptor related 1; Nuclear receptor subfamily 4, group A, member 2 isoform a
    Approved Symbol:
    NR4A2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 18
    Human (de-) phosphorylation sites: 18; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Parkinson disease, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03493 Entrez Gene ID: 4929 OMIM ID: 601828 Swissprot Accession: Q53RZ2; P43354; Q53EL4;