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Description for Protein NTRK2

neurotrophic tyrosine kinase, receptor, type 2
28 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • LRR: Leucine-rich repeats, outliers
  • IGC2: Immunoglobulin C-2 Type
  • TM: Transmembrane domain
  • Tyr_Kinase: tyrosine kinase domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.1
    KEGG - Orthology:
    K04360
    KEGG - Pathway(s):
    hsa04010; hsa04722
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    TRKB; BDNF/NT 3 growth factors receptor; Tyrosine kinase receptor B; GP145-TrkB; TrkB tyrosine kinase; Neurotrophic tyrosine kinase, receptor, type 2 isoform c precursor; Neurotrophic tyrosine kinase, receptor, type 2 isoform a precursor; Neurotrophic tyrosine kinase, receptor, type 2 isoform d precursor; Neurotrophic tyrosine kinase, receptor, type 2 isoform e precursor; Neurotrophic tyrosine kinase, receptor, type 2 isoform b precursor
    Approved Symbol:
    NTRK2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 10
    Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 4
    Human phosphorylation targets: 4; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Amitriptyline(db)

    Associated Genetic Diseases:

  • Obesity, hyperphagia, and developmental delay(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 5 : 1
  • Isoform 4 : 1
  • Isoform 3 : 2
  • Isoform 2 : 1
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 02712 Entrez Gene ID: 4915 OMIM ID: 600456 Swissprot Accession: Q8WXJ5; Q16620; Q548C2;