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Description for Protein NTRK1

neurotrophic tyrosine kinase, receptor, type 1
37 total interacting proteins; 20 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • LRR: Leucine-rich repeats, outliers
  • IG: Immunoglobulin
  • TM: Transmembrane domain
  • Tyr_Kinase: tyrosine kinase domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.1
    KEGG - Orthology:
    K03176
    KEGG - Pathway(s):
    hsa04010; hsa04144; hsa04210; hsa04722; hsa05200; hsa05216
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MTC; TRK1; DKFZp781I14186; TRKA; Tyrosine kinase receptor; TRK; Neurotrophic tyrosine kinase, receptor type 1; High affinity nerve growth factor receptor; TRK1 transforming tyrosine kinase protein; Neurotrophic tyrosine kinase, receptor, type 1 isoform 2; Neurotrophic tyrosine kinase, receptor, type 1 isoform 1; Neurotrophic tyrosine kinase, receptor, type 1 isoform 3; p140-TrkA
    Approved Symbol:
    NTRK1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 21
    Human (de-) phosphorylation sites: 21; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 2
    Human phosphorylation targets: 2; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Amitriptyline(db);
  • Imatinib(db)

    Associated Genetic Diseases:

  • Insensitivity to pain, congenital, with anhidrosis(Pd);
  • Thyroid carcinoma, familial medullary(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01869 Entrez Gene ID: 4914 OMIM ID: 191315 Swissprot Accession: P04629; A6NF12;