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Description for Protein NRAS

neuroblastoma RAS viral (v-ras) oncogene homolog
15 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/0)
(membrane: 1; platelet: 3)
Summary:
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RAS: Ras subfamily of RAS small GTPases
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07828
    KEGG - Pathway(s):
    hsa04010; hsa04012; hsa04062; hsa04360; hsa04370; hsa04530; hsa04540; hsa04650; hsa04660; hsa04662; hsa04664; hsa04720; hsa04722; hsa04730; hsa04810; hsa04910; hsa04912; hsa04916; hsa05200; hsa05211; hsa05213; hsa05214; hsa05215; hsa05216; hsa05218; hsa05219; hsa05220; hsa05221; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Oncogene NRAS; Neuroblastoma ras viral oncogene; NRAS1
    Approved Symbol:
    NRAS
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Colorectal cancer(Pd);
  • Thyroid carcinoma, follicular(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01273 Entrez Gene ID: 4893 OMIM ID: 164790 Swissprot Accession: P01111; Q5U091;