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Description for Protein ATP2A3

ATPase, Ca++ transporting, ubiquitous
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 8/2)
(alpha granules: 1; membrane: 2; platelet: 14; undefined: 1)
Summary:
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.3.8
    KEGG - Orthology:
    K05853
    KEGG - Pathway(s):
    hsa04020; hsa05010
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Sarco/endoplasmic reticulum Ca2+ -ATPase isoform c; Sarcoplasmic reticulum Ca(2+) ATPase 3; SERCA3; Calcium pump 3; SR Ca(2+) ATPase 3; EC 3.6.3.8; Sarco/endoplasmic reticulum Ca2+ -ATPase isoform a; Sarco/endoplasmic reticulum Ca2+ -ATPase isoform f; Sarco/endoplasmic reticulum Ca2+ -ATPase isoform d; Adenosine triphosphatase, calcium; Calcium-translocating P-type ATPase; Sarco/endoplasmic reticulum Ca2+ -ATPase; Sarco/endoplasmic reticulum Ca2+ -ATPase isoform b; Sarco/endoplasmic reticulum Ca2+ -ATPase isoform e
    Approved Symbol:
    ATP2A3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 7 : 8
  • Isoform 6 : 8
  • Isoform 5 : 7
  • Isoform 4 : 7
  • Isoform 3 : 8
  • Isoform 2 : 8
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 03568 Entrez Gene ID: 489 OMIM ID: 601929 Swissprot Accession: Q93084;