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Description for Protein NPR3

natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
4 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The family of natriuretic peptides (see MIM 108780) elicit a number of vascular, renal, and endocrine effects that are important in the maintenance of blood pressure and extracellular fluid volume. These effects are mediated by specific binding of the peptides to cell surface receptors in the vasculature, kidney, adrenal, and brain.[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12325
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Atrial natriuretic peptide clearance receptor; ANPRC; Atrionatriuretic peptide receptor, Type C; ANP-C; Natriuretic peptide receptor C; Atrial natriuretic peptide C-type receptor; ANP C-receptor
    Approved Symbol:
    NPR3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alpha-D-Mannose(db);
  • Fucose(db);
  • Nesiritide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00167 Entrez Gene ID: 4883 OMIM ID: 108962 Swissprot Accession: P17342; Q60I31;