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Description for Protein NPR2

natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
4 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • S_T_Y_Kinase: Protein kinase
  • unclassified specificity
  • CC: Coiled Coil
  • GuCyclase: Adenylyl-/guanylyl cyclase, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    4.6.1.2
    KEGG - Orthology:
    K12324
    KEGG - Pathway(s):
    hsa00230; hsa04270
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Atrionatriuretic peptide receptor, type B; Atrial natriuretic peptide receptor B; Guanylate cyclase; ANP-B; ANPRB; GC-B; Natriuretic peptide receptor; NPR-B
    Approved Symbol:
    NPR2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Erythrityl Tetranitrate(db);
  • Nesiritide(db)

    Associated Genetic Diseases:

  • Acromesomelic dysplasia, maroteaux type(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00166 Entrez Gene ID: 4882 OMIM ID: 108961 Swissprot Accession: P20594;