Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein NPM1

nucleophosmin (nucleolar phosphoprotein B23, numatrin)
49 total interacting proteins; 20 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K11276
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
Nucleophosmin family, member 1; Nucleophosmin; Nucleolar phosphoprotein B23; Numatrin; NPM; B23; Nucleolar protein NO38; MGC104254; Nucleophosmin/nucleoplasmin family, member 1; Nucleophosmin 1 isoform 1; Nucleophosmin 1 isoform 2; Nucleophosmin 1 isoform 3
Approved Symbol:
NPM1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 40
Human (de-) phosphorylation sites: 40; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Leukemia, acute myeloid(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01246 Entrez Gene ID: 4869 OMIM ID: 164040 Swissprot Accession: P06748; Q9BYG9;