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Description for Protein CNOT4

CCR4-NOT transcription complex, subunit 4
10 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene. (PubMed Links)
Domains and Motifs:
  • RRM: RNA recognition motif
  • RING: Ring finger
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.3.2.19
    KEGG - Orthology:
    K10643
    KEGG - Pathway(s):
    hsa03018
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CCR4 NOT transcription complex, subunit 4; Negative regulator of transcription 4; NOT4H; NOT4 (negative regulator of transcription 4) homolog; E3 ubiquitin protein ligase CNOT4; CCR4-associated factor 4; CLONE243; CCR4-NOT transcription complex, subunit 4 isoform b; CCR4-NOT transcription complex, subunit 4 isoform a; Potential transcriptional repressor NOT4Hp
    Approved Symbol:
    CNOT4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05369 Entrez Gene ID: 4850 OMIM ID: 604911 Swissprot Accession: O95628;