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Description for Protein NOS3

nitric oxide synthase 3 (endothelial cell)
20 total interacting proteins; 15 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/2)
(undefined: 2)
Summary:
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.14.13.39
KEGG - Orthology:
K13242
KEGG - Pathway(s):
hsa00330; hsa01100; hsa04020; hsa04370
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Nitric oxide synthase, endothelial; ENOS; EC-NOS; NOS type III; NOSIII; Endothelial NOS; eNOS; Constitutive NOS; cNOS
Approved Symbol:
NOS3
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 9
Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • (3S,5E)-3-propyl-3,4-dihydrothieno[2,3-f][1,4]oxazepin-5(2H)-imine(db);
  • (6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin(db);
  • 1,2,4-Triazole-Carboxamidine(db);
  • 2,4-Diamino-6-Phenyl-5,6,7,8,-Tetrahydropteridine(db);
  • 2-Aminothiazoline(db);
  • 2-Methyl-2,4-Pentanediol(db);
  • 2-Propanol, Isopropanol(db);
  • 3-Bromo-7-Nitroindazole(db);
  • 5,6-Cyclic-Tetrahydropteridine(db);
  • 5-Nitroindazole(db);
  • 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE(db);
  • 6-Nitroindazole(db);
  • 6s-5,6,7,8-Tetrahydrobiopterin(db);
  • 7-Nitroindazole(db);
  • 7-Nitroindazole-2-Carboxamidine(db);
  • Acetate Ion(db);
  • Cacodylate Ion(db);
  • ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE(db);
  • Ethylisothiourea(db);
  • Heme(db);
  • Hydroxydimethylarsine Oxide(db);
  • L-2-Amino-4-(Guanidinooxy)Butyric Acid(db);
  • L-Arginine(db);
  • L-Citrulline(db);
  • L-Homoarginine(db);
  • L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide(db);
  • L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide(db);
  • Miconazole(db);
  • N,N-dimethylarginine(db);
  • N-(3-(Aminomethyl)Benzyl)Acetamidine(db);
  • N-(Chlorophenyl)-N'-Hydroxyguanidine(db);
  • N-Omega-Hydroxy-L-Arginine(db);
  • N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine(db);
  • N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE(db);
  • N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N'-Nitroguanidine(db);
  • N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane(db);
  • N5-Iminoethyl-L-Ornithine(db);
  • Nitroarginine(db);
  • S,S'-(1,3-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea(db);
  • S,S'-(1,4-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea(db);
  • S-(Dimethylarsenic)Cysteine(db);
  • S-Ethyl-N-Phenyl-Isothiourea(db);
  • S-Isopropyl-Isothiourea(db);
  • Se-Ethyl-Isoselenourea(db);
  • Tetrahydrobiopterin(db)

    Associated Genetic Diseases:

  • Coronary spasms, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01224 Entrez Gene ID: 4846 OMIM ID: 163729 Swissprot Accession: P29474; A0S0A7; A0S0A8;