Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein NOS2

nitric oxide synthase 2, inducible
9 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.14.13.39
KEGG - Orthology:
K13241
KEGG - Pathway(s):
hsa00330; hsa01100; hsa04020; hsa04146; hsa05140; hsa05142; hsa05200; hsa05222
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Nitric oxide synthase 2A isoform 2; Nitric oxide synthase 2A isoform 1; NOS2; Nitric oxide synthase, macrophage; NOS2A inducible, hepatocyte; Hepatocyte NOS; iNOS; HEP-NOS; Inducible NOS; NOS type II
Approved Symbol:
NOS2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 7
Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • (2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine(db);
  • (3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine(db);
  • (3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PIPERIDINE(db);
  • (6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin(db);
  • 1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[PIPERIDINE-4,2'(1'H)-QUINAZOLINE]-4'-AMINE(db);
  • 1-[4-(AMINOMETHYL)BENZOYL]-5'-FLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLIN]-4'-AMINE(db);
  • 3-Bromo-7-Nitroindazole(db);
  • 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINE(db);
  • 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE(db);
  • 4-(1H-IMIDAZOL-1-YL)PHENOL(db);
  • 4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile(db);
  • 4r-Fluoro-N6-Ethanimidoyl-L-Lysine(db);
  • 5-(4'-AMINO-1'-ETHYL-5',8'-DIFLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE(db);
  • 5-Nitroindazole(db);
  • 6-Nitroindazole(db);
  • 7,8-Dihydro-L-Biopterin(db);
  • 7,8-dihydrobiopterin(db);
  • 7-Nitroindazole(db);
  • Aminoguanidine(db);
  • B-Octylglucoside(db);
  • Dexamethasone(db);
  • ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE(db);
  • ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE(db);
  • Ethylisothiourea(db);
  • Heme(db);
  • Imidazole(db);
  • L-Arginine(db);
  • L-Citrulline(db);
  • L-Thiocitrulline(db);
  • Miconazole(db);
  • N,N-dimethylarginine(db);
  • N-(3-(Aminomethyl)Benzyl)Acetamidine(db);
  • N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine(db);
  • N-Omega-Hydroxy-L-Arginine(db);
  • N-Omega-Propyl-L-Arginine(db);
  • N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDE(db);
  • N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE(db);
  • N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDE(db);
  • S-Ethylisothiourea(db);
  • Thiocoumarin(db)

    Associated Genetic Diseases:

  • Malaria, resistance to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01225 Entrez Gene ID: 4843 OMIM ID: 163730 Swissprot Accession: P35228;