Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein NOS1

nitric oxide synthase 1 (neuronal)
31 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. This gene encodes a nitric oxide synthase which is highly expressed in skeletal muscle. Genetic variations in this gene are associated with infantile hypertrophic pyloric stenosis type 1. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. (PubMed Links)
Domains and Motifs:
  • PDZ: Domain present in PSD-95, Dlg, and ZO-1/2.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.14.13.39
    KEGG - Orthology:
    K13240
    KEGG - Pathway(s):
    hsa00330; hsa01100; hsa04020; hsa04730; hsa04970; hsa05010; hsa05014
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    NOS; IHPS1; Neuronal nitric oxide synthase; Nitric-oxide synthase, brain; EC 1.14.13.39; NOS type I; Neuronal NOS; N-NOS; nNOS; Constitutive NOS; NC-NOS; bNOS; PNNOS; Nitric oxide synthase, penile neuronal
    Approved Symbol:
    NOS1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin(db);
  • 2'-Monophosphoadenosine 5'-Diphosphoribose(db);
  • 3-Bromo-7-Nitroindazole(db);
  • 5-N-Allyl-Arginine(db);
  • Acetate Ion(db);
  • Alpha-D-Mannose(db);
  • Flavin-Adenine Dinucleotide(db);
  • Formic Acid(db);
  • Heme(db);
  • L-Citrulline(db);
  • L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide(db);
  • L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide(db);
  • N-(3-(Aminomethyl)Benzyl)Acetamidine(db);
  • N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine(db);
  • N-Butyl-N'-Hydroxyguanidine(db);
  • N-Isopropyl-N'-Hydroxyguanidine(db);
  • N-Omega-Hydroxy-L-Arginine(db);
  • N-Omega-Propyl-L-Arginine(db);
  • N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine(db);
  • N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE(db);
  • N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N'-Nitroguanidine(db);
  • N5-(1-Imino-3-Butenyl)-L-Ornithine(db);
  • Nitroarginine(db);
  • Riboflavin Monophosphate(db);
  • S-Ethyl-N-Phenyl-Isothiourea(db);
  • S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea(db)

    Associated Genetic Diseases:

  • Pyloric stenosis, infantile hypertrophic, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01226 Entrez Gene ID: 4842 OMIM ID: 163731 Swissprot Accession: P29475; B3VK56; A0PJJ7;