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Description for Protein NONO

non-POU domain containing, octamer-binding
16 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 3)
Summary:
This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RRM: RNA recognition motif
  • CC: Coiled Coil

  • Gene Ontology:
    Gene Ontology Annotations

    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K13214
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Nuclear RNA binding protein 54 kd; NRB54; NMT55; P54NRB; P54; 54 kDa nuclear RNA and DNA binding protein; DNA binding P52/P100 complex 52 kDa subunit; 55 kDa nuclear protein; Non POU domain containing, octamer-binding; Non Pou domain-containing octamer (ATGCAAAT) binding protein
    Approved Symbol:
    NONO
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 20
    Human (de-) phosphorylation sites: 20; No platelet phosphorylation sites

    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available


    Associated Genetic Diseases:

    None Available
    Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
  • Additional Identifiers:

    HPRD: 02098 Entrez Gene ID: 4841 OMIM ID: 300084 Swissprot Accession: Q15233B7Z4C2