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Description for Protein NQO2

NAD(P)H dehydrogenase, quinone 2
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(secretome: 2)
Summary:
NQO2 (EC 1.10.99.2) is a flavoprotein that catalyzes the 2-electron reduction of various quinones, redox dyes, and the vitamin K menadione. NQO2 predominantly uses dihydronicotinamide riboside (NRH) as the electron donor (summary by Wu et al., 1997 [PubMed 9367528]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.10.99.2
KEGG - Orthology:
K08071
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
NRH:quinone oxidoreductase 2; NAD(P)H:menadione oxidoreductase 1, dioxin inducible 2; Dihydronicotinamide riboside:quinone oxidoreductase 2; QR2
Approved Symbol:
NQO2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 7
Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • (3S)-3-hydroxy-1-methyl-2,3-dihydro-1H-indole-5,6-dione(db);
  • 10-Propargyl-5,8-Dideazafolic Acid(db);
  • 5,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one(db);
  • 6-methoxy-9-methyl[1,3]dioxolo[4,5-h]quinolin-8(9H)-one(db);
  • CB1954(db);
  • Flavin-Adenine Dinucleotide(db);
  • Melatonin(db);
  • Menadione(db);
  • N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]acetamide(db);
  • N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide(db);
  • NADH(db);
  • Primaquine(db);
  • Resveratrol(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01190 Entrez Gene ID: 4835 OMIM ID: 160998 Swissprot Accession: P16083;